Studio Polmone COR-RET
COR-RET
Principal investigar dr. Citarella (GdP Toracico)
COR-RET (Observational study investigating CORrelation between total cancer volume and clinical response and toxicity in patients with RET positive Non-Small Cell Lung Cancer upon Pemetrexed-based chemotherapy) si concentra sul carcinoma polmonare non a piccole cellule (NSCLC) con riarrangiamento RET, una forma rara di tumore sensibile a inibitori specifici (TKI). L'ipotesi è che il volume totale del tumore possa predire l'efficacia e la tossicità del trattamento standard. Svelare questo nesso permetterebbe di identificare strategie per modulare la dose di chemioterapia e migliorare la tolleranza e la durata del trattamento. I risultati potrebbero fornire strumenti semplici e utili per personalizzare il trattamento in questi pazienti.
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The COR-RET study (Observational study investigating CORrelation between total cancer volume and clinical response and toxicity in patients with RET positive Non-Small Cell Lung Cancer upon Pemetrexed-based chemotherapy) focuses on Non-Small Cell Lung Cancer (NSCLC) with RET rearrangement, a rare type of tumor sensitive to specific inhibitors (TKIs). The hypothesis is that total tumor volume could predict the efficacy and toxicity of standard treatment. Unveiling this connection would allow the identification of strategies to adjust chemotherapy doses, improving tolerance and extending treatment duration. The results could provide simple and valuable tools for tailoring treatment in these patients.
