Thursday, December 05, 2019
IRST - Meldola
Useful contacts

Dr Paola Ulivi - Molecular Diagnostics Referring Biologist
phone 39 0543 739277
phone 39 0543 739980
from monday to friday 8:30 a.m. - 5:00 p.m.

Dr Sara Bravaccini - Cellular Diagnostics Referring Biologist
phone 39 0543 739226
from monday to friday 8:30 a.m. - 5:00 p.m.

Dr Claudia Rengucci - Biotechnologist
phone 39 0543 739228
from monday to friday 8:30 a.m. - 5:00 p.m.


Dr Daniele Calistri

Dr Paola Ulivi
(Molecular Diagnostics Referring Biologist)

Dr Sara Bravaccini
(Cellular Diagnostics Referring Biologist)

Dr Maurizio Puccetti
(Referring Pathologist)

Dr Giovanni Brigliadori

Dr Laura Capelli

Dr Elisa Chiadini

Dr Claudia Rengucci

Dr Maria Maddalena Tumedei

Diagnostica molecolare

Italian version

What is molecular diagnostics?
Molecular diagnostics is the technique used to study the genome (DNA) of a living organism that contains the instructions that regulate its development and function.

What is biomolecular diagnosis used for?
The analysis of the genome structure and organization represents an important step in the clinical and diagnostic evaluation of a growing number of genetic diseases. In addition, more and more drugs are being identified whose mechanisms of action are directed against specific biomolecular targets. It is essential to know the nature and status of these biological targets in order to adopt the most appropriate therapeutic strategy.  Such information is provided by the complex biological and molecular analyses performed in the Biosciences Laboratory at IRST and represents an invaluable aid to clinical practice.

Biomolecular Diagnostics
The Biomolecular Diagnostics sector of the Biosciences Laboratory is involved in the identification of tumor biomolecular alterations that have different roles in clinical practice, e.g. prognostic and predictive biomolecular markers, diagnostic markers, markers of treatment-related toxicity, etc.
Given our ever-increasing knowledge about response to drugs, it is essential to characterize tumors for different markers through the use of complex biomolecular profiles to guarantee a correct diagnosis.
Within these molecular profiles there are biomarkers not only correlated with prognosis or predictive or response, but ones that can also predict toxicity and/or the capacity to efficiently metabolize cancer drugs, enabling complex diagnostic profiles based on genomic, genetic and molecular data to be built up.  Taking in account its dual role in diagnostics and research, and thanks also to the collaboration of all the Oncology Departments of Romagna, the Biosciences Laboratory continues to search for new ways in which to support clinical practice and to update its know-how on the latest molecular tests required for new targeted therapies.
The list of the available analyses is constantly updated in order to provide clinicians with the most advanced tests for a correct molecular diagnosis of tumours. In addition, many of the analyses in use undergo quality controls in order to guarantee the best possible results. Given the type of institute that IRST is, and the need to improve and optimize the analyses performed, the Biosciences Laboratory has always participated in external quality assessment (EQA) projects, acting, on some occasions, as coordinating center. In particular, the Laboratory has adhered to quality control projects sponsored by the Italian Association of Medical Oncology (AIOM) and the Italian Society of Pathology and Diagnostic Cytology (SIAPEC) for the analyses of mutations upon which the choice of cancer treatment is based.  It also participates in European quality controls on standard procedures that form the basis of molecular biology (DNA/RNA extraction and PCR amplification) required for many of the analysis currently used in the Laboratory.
Together with the Pathology Department of Addarii Institute (S. Orsola-Malpighi Hospital, Bologna) and other centers in Emilia-Romagna, a quality control network has been developed for the main molecular techniques currently in use in oncological clinical practice.
The laboratory has successfully passed all the quality controls to which it has been subjected and is considered a national reference center for the majority of the diagnostic tests performed.

Who are the services of the biomolecular diagnostics sector aimed at?
The area of biomolecular diagnostics is aimed at cancer patients who require in-depth diagnostic tests to more effectively personalize therapies. Test are carried out at the request of medical oncologists and other specialists both within and external to the Institute. Thus, requests from patients will not be accepted.

The Biosciences Laboratory at IRST currently performs biomolecular analyses for the following tumors:

  • Brain tumors
  • Colorectal cancer
  • Melanoma
  • Gastrointestinal stromal tumors (GIST)
  • Lung cancer
  • Head and neck cancer
  • Thyroid cancer
  • Bladder cancer

 Link utili:

Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (I.R.S.T.) S.r.l.
Sede legale: 47014 Meldola (FC) Via Piero Maroncelli, 40
Capitale Sociale interamente versato Euro 20.000.000,00 - R.E.A. 288572 (FC)
Reg. Imprese FC/Cod. Fisc./Partita IVA 03154520401
Tel. 0543 739100 - Fax 0543 739123
e-mail: - internet: